Portfolio
Taken in May 2023 
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portfolio
publications
The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization Permalink
Published in Cell Reports, 2023
This paper is about the role of intirnsically disordered regions (IDRs) in the oligomerization of coronin. This trait is observed in yeast but not in murine. The IDR can facilitate the packing of coiled-coil domain, and this effect is strong due to the deficiency of coiled-coil domain in yeast. In murine, the coiled-coil domain adopts perfect packing pattern, which caused selection strength on the length of IDR evolutionally. The coarse-grained model adopts a hybrid strategy, which treats folded domain with Gō-like model and IDRs with adapted Kim-Hummer model.
PS: a very interesting work if you believe in evolution! :)
Recommended citation: Han, X.; Hu, Z.; Surya, W.; Ma, Q.; Zhou, F.; Nordenskiöld, L.; Torres, J.; Lu, L.; Miao, Y. (2023). "The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization." Cell Reports. 42(6).
Refined Bonded Terms in Coarse-Grained Models for Intrinsically Disordered Proteins Improve Backbone Conformations Permalink
Published in The Journal of Physical Chemistry B, 2024
This paper is about the refined coarse-grained (CG) bonded potentials for disordered proteins. It achieves near-quantitative accuracy with secondary structure propensity estimated by NMR data, and captures the transient secondary structure of p53.
NOTE: This is challenging even in atomistic model!
Recommended citation: Zixin Hu, Tiedong Sun, Wenwen Chen, Lars Nordenskiöld, and Lanyuan Lu (2024). "Refined Bonded Terms in Coarse-Grained Models for Intrinsically Disordered Proteins Improve Backbone Conformations." The Journal of Physical Chemistry B. 128(27).
Systematic Investigation of the Liquid–Liquid Phase Separation Propensity of Intrinsically Disordered Proteins by Molecular Simulations Permalink
Published in The Journal of Physical Chemistry B, 2025
This paper is about the relation between liquid-liquid phase separation (LLPS) propensity and multivalency of disordered proteins. It provides a recommended multivalence cutoff for LLPS.
Recommended citation: Zixin Hu, Tiedong Sun, Lars Nordenskiöld, and Lanyuan Lu (2025). "Systematic Investigation of the Liquid–Liquid Phase Separation Propensity of Intrinsically Disordered Proteins by Molecular Simulations." The Journal of Physical Chemistry B. 129, 33, 8299–8317.
talks
Talk 1 on Relevant Topic in Your Field
Published:
This is a description of your talk, which is a markdown file that can be all markdown-ified like any other post. Yay markdown!
Conference Proceeding talk 3 on Relevant Topic in Your Field
Published:
This is a description of your conference proceedings talk, note the different field in type. You can put anything in this field.
teaching
Teaching experience as Teaching Assistant (416 hours)
Undergraduate course, School of Biological Sciences, Nanyang Technological University, 2020
- Principle of genetics: tutorial
- Introduction to computational thinking (python course): computation lab
- Biophysical chemistry: tutorial, computation lab
- Biostatistics: computation lab
- Topics in cell biology: tutorial
- Biochemistry: tutorial